Meiotic spindle assembly checkpoint and aneuploidy in males versus females
نویسندگان
چکیده
منابع مشابه
Meiotic spindle, spindle checkpoint and embryonic aneuploidy.
In mitosis, a spindle checkpoint plays important roles at the metaphase-anaphase transition to ensure the formation of a bipolar spindle, the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase. Components of the spindle checkpoint were first identified through genetic screens in budding yeast and some ch...
متن کاملThe spindle assembly checkpoint
Italian in 1954, so Imanishi turned to the exploration of the unexplored wide range of Karakorum Himalayas, traversing the three major glaciers in 1955. Then, in 1958, Imanishi and Itani went to Africa for the first time. In the same year, Nishibori led the all-Japanese team which succeeded in the first over-wintering stay in Antarctica. Kuwabara led the Himalayan expedition of AACK to the firs...
متن کاملThe Spindle Assembly Checkpoint
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint ...
متن کاملSpindle Assembly Checkpoint in oocytes and zygotes and its importance for human aneuploidy
The surveillance mechanism called Spindle Assembly Checkpoint (SAC) monitors the status of the division spindle and prevents anaphase entry in the presence of anomalies that could result in erroneous segregation of the chromosomes. Disturbances in SAC activity during female meiosis promotes formation of aneuploid oocytes and results in associated reproductive disorders like pregnancy loss or bi...
متن کاملSpindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans
Homologue synapsis is required for meiotic chromosome segregation, but how synapsis is initiated between chromosomes is poorly understood. In Caenorhabditis elegans, synapsis and a checkpoint that monitors synapsis depend on pairing centers (PCs), cis-acting loci that interact with nuclear envelope proteins, such as SUN-1, to access cytoplasmic microtubules. Here, we report that spindle assembl...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2018
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-018-2986-6